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High-Throughput Synchronized Three-Dimensional Fly-Scanning Microscopy for Neural Mapping — A Report on the 227th Youth Academic Salon of CBEIS, Zhejiang University

【Publisher】:生物医学工程与仪器科学学院【Time】:2026-05-29 【Frequency】:10

On May 28, 2026, at 10:00 a.m., the latest session of the Youth Academic Salon of the College of Biomedical Engineering & Instrument Science (CBEIS), Zhejiang University, held as part of the series of activities to enhance graduate students' research capabilities, was successfully held in the first-floor lecture hall of the Zhou Yiqing Science and Technology Building. The salon featured a special invited academic talk by Dr. Xu Cheng, Researcher at the Institute of Advanced Technology, Chinese Academy of Sciences, titled High-Throughput Synchronized Three-Dimensional Fly-Scanning Microscopy and Its Applications in Neural Mapping. The talk was hosted by Researcher Hyeon Jeong Lee.


Dr. Xu systematically introduced the team's recently developed synchronized fly-scanning high-speed imaging technology (VISoR), which is designed for mapping mesoscale neural connectivity and enables high-throughput three-dimensional imaging of biological tissues at high speed. This technology has revealed complex projection trajectories and patterns from the thalamus to the cortex in the macaque brain. Furthermore, the team's further developed blockface-VISoR imaging technology enables comprehensive analysis of the entire mouse body. Leveraging its advantages in subcellular resolution and high compatibility with labeling strategies, this technology has been applied to map complex neural connectivity throughout the central and peripheral nervous systems of mice, as well as to conduct structural and functional analyses of thoracic spinal nerves, systemic sympathetic nerves, and the vagus nerve.